Albrecht Durer drew “Self-Portrait” in 1521 during a trip to Zeeland. During this trip, Durer caught an infection similar to Malaria. The comment inscribed in the drawing reads “Do der gelb fleck ist und mit dem finger drawff do ist mir we” means “This is the yellow spot and when I press my finger on it, it hurts”. It is believed that the drawing an note was meant to be sent to a doctor to help with the diagnosis. Sadly, Albrecht would never fully recover from the infection, and would die 7 years later in 1528.